Search results for "ACACA gene"

showing 2 items of 2 documents

Full-length sequencing and identification of novel polymorphisms in the ACACA gene of Valle del Belice sheep breed

2017

The essential role of the acetyl-CoA carboxylase (ACACA) enzyme in milk fatty acid (FA) synthesis suggests that it may be responsible for the phenotypic variability observed in milk. Before attempting association analyses between this gene and/or enzyme and phenotypic traits, a study on the genetic variability within this locus is required. The aim of this work was to sequence the entire coding region of ACACA gene in Valle del Belice sheep breed to identify polymorphic sites. A total of 51 coding exons of ACACA gene were sequenced in 32 individuals of Valle del Belice sheep breed. Sequencing analysis and alignment of obtained sequences showed the presence of 23 polymorphic sites. The most …

0301 basic medicineGenetic MarkerssheepSingle-nucleotide polymorphismLocus (genetics)BiologyBreedingPolymorphism Single Nucleotide03 medical and health sciencesExonSettore AGR/17 - Zootecnica Generale E Miglioramento Geneticosingle-nucleotide polymorphismsGeneticsAnimalsGenetic variabilityGeneACACA gene single-nucleotide polymorphisms sheep Valle del Belice breedGeneticsValle del Belice breedACACAHaplotype0402 animal and dairy science04 agricultural and veterinary sciencesExonsSequence Analysis DNAsingle-nucleotide polymorphism040201 dairy & animal scienceACACA gene; sheep; single-nucleotide polymorphisms; Valle del Belice breed030104 developmental biologyPhenotypeAmino Acid SubstitutionHaplotypesGenetic markerMutationACACA geneAcetyl-CoA Carboxylase
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Analysis of acetyl-CoA carboxylase gene polymorphisms in Valle del Belice dairy breeds

2015

Acetyl-CoA carboxylase is the flux-determining enzyme in the regulation of fatty acid synthesis within animal tissues. The expression of the mammary gland isoform of this enzyme, during lactation, is regulated by the acetyl-CoA carboxylase-α (ACACA) gene. The ovine ACACA gene, with 51 coding exons, is responsible for phenotypic variability observed in milk fat content and milk fatty acids (FAs) composition. However, before attempting association analyses between this enzyme and phenotypic traits of interest, a study on the genetic variability within this locus is required. The aim of this work was to sequence the encoding region of ACACA gene in Valle del Belice dairy ewes in order to ident…

Settore AGR/17 - Zootecnica Generale E Miglioramento GeneticoSNPs ACACA gene Valle del Belice dairy sheep breed
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